Monosodium glutamate
DL-monosodium glutamate
CAS: 32221-81-1
Molecular Formula: C5H8NNaO4
Monosodium glutamate - Names and Identifiers
| Name | DL-monosodium glutamate |
| Synonyms | Sodium Glutamate Monosodium glutamate Monosodium Glutamate sodium glutamate(1-) sodium acid l-glutamate Monosodium DL-glutamate DL-monosodium glutamate disodium 2-aminopentanedioate Sodium 5-oxido-5-oxonorvaline Glutamic acid, monosodium salt sodium 2-amino-4-carboxybutanoate Glutamic acid, monosodium salt, DL- α-Amiopetandioic acid monosodium salt Monosodium glutamate with other flavour-enhancers |
| CAS | 32221-81-1 |
| EINECS | 200-533-0 |
| InChI | InChI=1/C5H9NO4.Na/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);/q;+1/p-1 |
Monosodium glutamate - Physico-chemical Properties
| Molecular Formula | C5H8NNaO4 |
| Molar Mass | 169.11109 |
| Stability | Stable. Incompatible with strong oxidizing agents |
| Physical and Chemical Properties | White prismatic crystal or crystalline powder, odorless, special meat flavor. The relative density is 1.635, the melting point is 195 ° C., and the filling specific volume is 1.20. Soluble in water, 5% aqueous solution PH 6.7-7.2, difficult to dissolve in ethanol and ether. He lost crystal water at 120 ℃, and intramolecularly dehydrated into sodium pyroglutamate at 150-160 ℃, which lost flavor and decomposed into pyrrole at about 270 ℃. Mouse oral LD5016.2g/kg,ADI does not require special provisions (FAO/WHO,1994). |
| Use | Used as a food flavoring agent |
Monosodium glutamate - Upstream Downstream Industry
| Raw Materials | L-Glutamic acid Sodium carbonate Starch potato Charcoal Sulfuric acid Urea Sodium hydroxide Hydrochloric acid Ammonia |
Monosodium glutamate - Category
Authoritative Data Verified Data
pharmaceutical excipients, flavors and cosolvents.
Last Update：2024-01-02 23:10:35
Monosodium glutamate - Standard
Authoritative Data Verified Data
This product is The monosodium salt of L-2-amino Glutaric acid. The content of C5H8NNa04 • H20 shall be between 99.0% and 100.5% calculated as dry.
Last Update：2024-01-02 23:10:35
Monosodium glutamate - Trait
Authoritative Data Verified Data
- This product is white crystal or crystalline powder.
- This product is soluble in water, slightly soluble in ethanol.
specific rotation
take this product, precision weighing, add 2mol/L hydrochloric acid solution to dissolve and quantitatively dilute to make about O in each lml. 1g of the solution was measured according to the law (General rule 0621), and the specific rotation was 24.8 ° to 25.3 °.
Last Update：2022-01-01 11:58:35
Monosodium glutamate - Differential diagnosis
Authoritative Data Verified Data
- take about 5mg of this product, add 1 ml of water to dissolve, add several drops of ninhydrin test solution, heat, the solution appears blue to purple blue.
- appropriate amounts of this product and the reference product of sodium glutamate were dissolved and diluted with water to prepare a solution containing about 0.4mg per 1 ml as the test solution and the reference solution. According to the chromatographic condition test under other amino acids, the position and color of the main spot of the test solution should be the same as that of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 959).
- the product of the aqueous solution of sodium salt identification (1) of the reaction (General 0301).
Last Update：2022-01-01 11:58:36
Monosodium glutamate - Exam
Authoritative Data Verified Data
pH
take l.Og of this product, Add 10ml of water to dissolve, and measure it according to law (General rule 0631). The pH value should be 6.7~7.2.
transmittance of solution
take l.Og of this product, add water 10ml to dissolve, according to UV-visible spectrophotometry (General rule 0401), determine the transmittance at the wavelength of 430mn, not less than 98.0%.
chloride
take 0.10g of this product and check it according to law (General rule 0801). Compared with the control solution made of 0.05% of standard sodium chloride solution, it should not be more concentrated ().
sulfate
take 0.5g of this product and check it according to law (General rule 0802). Compared with the control solution made of 0.03% of standard potassium sulfate solution, it should not be more concentrated ().
ammonium salt
take 0.10g of this product and check it according to law (General rule 0808). Compared with the control solution made of 0.02% of standard ammonium chloride solution, it shall not be deeper ().
other amino acids
take an appropriate amount of this product, add water to dissolve and dilute to make a solution containing about 10 mg per lml as a test solution; Take 1ml for precision measurement and put it in a 200ml measuring flask, dilute to scale with water, shake, as a control solution; Take the appropriate amount of sodium glutamate and aspartic acid in the same flask, water was added to dissolve and diluted to prepare a solution containing about 0.4mg each per 1ml as a system-suitable solution. According to the thin layer chromatography (General 0502) test, absorb the above three solutions each 5 u1, respectively, on the same silica gel G thin layer plate, with n-butanol-water-glacial acetic acid (2:1:1) to develop, spread, dry, spray with ninhydrin in acetone solution (1-50), heat at 80°C until spots appear, and immediately inspect. The control solution should show a clear spot, and the system applicable solution should show two completely separated spots. If the test solution shows impurity spots, the color should not be deeper (0.5%) than the main spot of the control solution.
loss on drying
take this product, drying at 97~99°C for 5 hours, loss of weight shall not exceed 0.1% (General rule 0831).
Iron Salt
take l.Og of this product and check it according to law (General rule 0807). Compared with the control solution made of 1.0 ml of standard iron solution, it shall not be deeper (0.001%).
Heavy metals
take l.Og of this product, add 23ml of water to dissolve, add 2ml of acetate buffer (pH 3.5), and check according to law (General rule 0821 first law), containing heavy metals not more than 10 parts per million.
arsenic salt
take 2.0g of this product, add 23ml of water to dissolve, add 5ml of hydrochloric acid, check according to law (General rule 0822 first law), should comply with the provisions (0.0001%).
bacterial endotoxin
take this product, check according to law (General 1143), each lg of sodium glutamate containing endotoxin should be less than 25EU. (For injection)
Last Update：2022-01-01 11:58:37
Monosodium glutamate - Content determination
Authoritative Data Verified Data
take this product about 80mg, precision determination, add anhydrous formic acid 3ml dissolved, add glacial acetic acid 30ml, according to the potentiometric titration method (General rule 0701), with perchloric acid titration solution (0.1 mol/L) titration, and the results of the titration were corrected with a blank test. Per 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 9.357mg of C5H8NNao4.H20.
Last Update：2022-01-01 11:58:37
Monosodium glutamate - Category
Authoritative Data Verified Data
amino acid drugs.
Last Update：2022-01-01 11:58:37
Monosodium glutamate - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:58:37
Monosodium glutamate - Sodium glutamate injection
Authoritative Data Verified Data
This product is a sterilized aqueous solution of sodium glutamate, or a sterilized aqueous solution made of glutamic acid and an appropriate amount of sodium hydroxide. The content of sodium glutamate (C5H8NNa04) shall be between 95.0% and 105.0% of the labeled amount.
trait
This product is colorless to yellowish clear liquid.
identification
- take 1 drop of this product, dilute with 2ml of water, add about 2mg of ninhydrin, heat, the solution appears blue to purple blue.
- take this product, according to the sodium glutamate identification (2) test, showed the same results.
- This product shows the reaction of sodium salt identification (1) (General rule 0301).
examination
- the pH value should be 7.5 to 8.5 (General 0631).
- the color of this product, compared with the yellow No. 1 Standard Colorimetric liquid (General Principles 0901 first method), should not be deeper.
- bacterial endotoxin take this product, check according to law (General 1143), each lg of sodium glutamate containing endotoxin should be less than 25EU.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
take 15ml of this product, put it in a 50ml measuring flask, add 10ml of hydrochloric acid, dilute it with water to the scale, shake it, determine the optical rotation according to law (General rule 0621), multiply by 11.972, that is, the Weight (g) of the product containing C5H8NNa04 per 100ml.
category
Same as glutamic acid.
specification
20ml:5.75g
storage
light shielding, closed storage.
Last Update：2022-01-01 11:58:38
Monosodium glutamate - Reference Information
| use | sodium glutamate is the most widely used flavor agent at home and abroad. when it coexists with salt, it can enhance its flavor effect. when it is used together with sodium 5 '-inosine or sodium 5'-guanosine, it has more multiplication effect. China's regulations can be used in all kinds of food according to the production needs of the appropriate amount. Used as food flavoring agent |
| production method | at present, rice, starch or molasses are used as raw materials to prepare:(1) starch saccharification. The saccharification of starch is mostly by double enzyme method. Rice is directly blended into starch slurry with relative density of 1.11(14 ° Bé) after soaking, sanding or starch, adding α-amylase to liquefy for 15-20min at PH4.5 and 90 ℃, then heating to 100 ℃ for 5min. After feeding, the filter residue can be used as feed, β-amylase is added, and saccharification is carried out at 60 ℃ for 12h, after the temperature is raised to 100 ℃, the enzyme is killed and then cooled and clarified. The supernatant liquid is directly put into the sugar solution storage tank. The precipitate liquid is added with filter aid diatomite and then pressure-filtered. The starch sugar conversion rate can reach 92%. (2) glutamic acid fermentation. About 15% of glucose is used as the carbon source, and an appropriate amount of inorganic salt and biotin are added to form a fermentation medium. After being eliminated and cooled to 40 ℃, it is sent to a sterilized fermentation empty tank, and the added liquid ammonia is used as the nitrogen source. Inoculate glutamic acid-producing bacteria cultured by secondary expansion, ventilate and ferment for 30 hours, the sugar-acid conversion rate can reach 50%, and the acid production level is about 7.0%-7.5%. The PH of fermentation process is controlled at 7.0-7.2, the temperature is controlled at 32-34 ℃ in the early stage and 34-37 ℃ in the later stage. (3) Extraction of glutamic acid. The extraction of glutamic acid is now generally by freezing isoelectric-ion exchange method. The fermentation broth is slowly stirred and cooled to 5 ℃ with frozen brine in an isoelectric tank, and the PH is adjusted to 3.22 (isoelectric point) with sulfuric acid. After 8 hours of precipitation, the precipitate is centrifuged to obtain crude glutamic acid. After the mother liquor and supernatant are mixed, the ion exchange resin is exchanged and washed with ammonia water. The front stream is merged into the supernatant and then onto the column, and the back stream and ammonia water are used as eluent, the high fraction and the fermentation broth are returned to the isoelectric tank, and the extraction rate can reach 88%-90%. (4) glutamic acid refining. Add glutamic acid to a neutralization tank filled with 60-65 ℃ bottom water, stir, and slowly add soda ash solution to neutralize until PH6.2-6.4, and the concentration of the neutralization solution is controlled at a relative density of 1.17-1.18(21-22 ° Bé); To be cooled to below 50 ℃, add an appropriate amount of sodium sulfide solution to remove iron, then use crude glutamic acid to adjust the PH to 6.2-6.4, and raise the temperature to 60 ℃, then add powdered activated carbon, after stirring for 0.5h, it is sent to a filter press for filtration, and then the filtrate is decolorized with a granular activated carbon column for the second time to obtain a clear liquid. The clear liquid is sent to a vacuum crystal boiling pot and evaporated and concentrated to a relative density of 1.28(31.5 ° Bé) at 60-70 ℃. 0.36-0.542mm crystal seeds are added and then evaporated and crystallized. During this period, hot water is used for crystal killing and a certain amount of clear liquid is added. After discharging, crystallized monosodium glutamate is obtained, mother liquor or after decolorization and then evaporation and crystallization, the refining yield can reach 92% of the theoretical amount. |
Last Update：2024-04-09 21:54:55
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Product Name: Glutamic acid sodium salt Visit Supplier Webpage Request for quotationCAS: 32221-81-1
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View History
Monosodium glutamate
AGS 200
Citrus sinensis Oil
ISOPROPYL TITANATE(IV)
Anagrelide Hydrochloride
25276-70-4
AGS 200
Citrus sinensis Oil
ISOPROPYL TITANATE(IV)
Anagrelide Hydrochloride
25276-70-4
Raw Materials for Monosodium glutamate